Long-term haemodynamic effects of amlodipine at rest and during exercise in essential hypertension

P Lund-Johansen; P Omvik; W White; O Digranes; B Helland; O Jordal; T Stray

Long-term haemodynamic effects of amlodipine at rest and during exercise in essential hypertension

Postgrad Med J. 1991:67 Suppl 5:S20-3.

Authors

P Lund-Johansen¹, P Omvik, W White, O Digranes, B Helland, O Jordal, T Stray

Affiliation

¹ Medical Department, Section of Cardiology, Haukeland Hospital, Bergen, Norway.

PMID: 1839433

Abstract

Amlodipine administered once daily (5-10 mg) lowered blood pressure and reduced total peripheral resistance in patients with mild-to-severe essential hypertension without any reflex tachycardia. Heart pump function was maintained at rest and during exercise with a trend towards an increase in cardiac and stroke index. Amlodipine was effective and well tolerated in both young and elderly hypertensive patients with no reports of unpleasant vasodilator-related side effects.

MeSH terms

Adult
Amlodipine
Calcium Channel Blockers / therapeutic use*
Drug Administration Schedule
Female
Heart / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hypertension / drug therapy*
Male
Middle Aged
Nifedipine / analogs & derivatives*
Nifedipine / therapeutic use
Physical Exertion / physiology*
Stroke Volume / drug effects
Time Factors
Vascular Resistance / drug effects

Substances

Calcium Channel Blockers
Amlodipine
Nifedipine