Studies on a new biosynthetic pathway for menaquinone

J Am Chem Soc. 2008 Apr 30;130(17):5614-5. doi: 10.1021/ja710207s. Epub 2008 Apr 8.

Abstract

Menaquinone is biosynthesized from chorismate via a new pathway involving 1,4-dihydroxy-6-naphthoate in Streptomyces and presumably in pathogenic bacteria Helicobacter and Campylobacter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Campylobacter / metabolism
  • Carbon / chemistry
  • Carbon Radioisotopes / chemistry
  • Chorismic Acid / chemistry
  • Chorismic Acid / metabolism*
  • Glucose / chemistry
  • Helicobacter / metabolism
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Naphthols / chemistry
  • Naphthols / metabolism*
  • Streptomyces / metabolism
  • Vitamin K 2 / chemistry
  • Vitamin K 2 / metabolism*
  • Vitamins / biosynthesis*
  • Vitamins / chemistry

Substances

  • Carbon Radioisotopes
  • Naphthols
  • Vitamins
  • Vitamin K 2
  • Carbon
  • Chorismic Acid
  • Glucose