Membrane proteins as diagnostic biomarkers and targets for new therapies

Curr Opin Mol Ther. 2008 Apr;10(2):116-23.

Abstract

Membrane proteins, especially plasma membrane proteins, form one of the most interesting classes of proteins among disease biomarker candidates. Because of their localization on the surface of cells and organelles, membrane proteins also represent potential drug targets. In this review, developments in the characterization of membrane proteins and their role in the treatment of disease, in particular cancer treatment, are presented.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis*
  • Humans
  • Membrane Proteins / analysis*
  • Membrane Proteins / drug effects
  • Neoplasms / drug therapy
  • Protein Processing, Post-Translational

Substances

  • Biomarkers
  • Membrane Proteins