Botulinum toxin type A in the healing of ulcer following oro-mandibular dyskinesia in a patient in a vegetative state

J Rehabil Med. 2008 Apr;40(4):315-6. doi: 10.2340/16501977-0190.

Abstract

Objective: Use of botulinum toxin is expanding as clinical studies demonstrate new potential therapeutic applications. In rehabilitation, botulinum toxin is predominantly used as adjunct therapy for the treatment of spasticity, but it may prove useful for other atypical clinical situations.

Case history: A 73-year-old man had a severe sub-arachnoid haemorrhage following the rupture of a giant aneurism of the middle left cerebral artery. Clinically, the patient presented a vegetative state and an oro-mandibular dyskinesia that produced a chronic ulcer on the lower lip. As treatment for this dyskinesia, a total of 320 U botulinum toxin type A were injected into the upper and lower orbicularis oris and masseter muscles.

Results and discussion: This treatment allowed for application of topical medication and subsequently, ulcer healing. Botulinum toxin type A may be an important therapeutic aid for clinicians faced with treating persistent pathological conditions caused by dyskinesia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Botulinum Toxins, Type A / administration & dosage
  • Botulinum Toxins, Type A / therapeutic use*
  • Chronic Disease
  • Dyskinesias / complications
  • Dyskinesias / physiopathology
  • Humans
  • Lip Diseases / drug therapy*
  • Lip Diseases / etiology
  • Lip Diseases / physiopathology
  • Male
  • Masticatory Muscles / drug effects
  • Masticatory Muscles / physiopathology
  • Neuromuscular Agents / administration & dosage
  • Neuromuscular Agents / therapeutic use*
  • Oral Ulcer / drug therapy*
  • Oral Ulcer / etiology
  • Oral Ulcer / physiopathology
  • Persistent Vegetative State / complications
  • Persistent Vegetative State / physiopathology

Substances

  • Neuromuscular Agents
  • Botulinum Toxins, Type A