Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia

Antimicrob Agents Chemother. 2008 Jun;52(6):2260-2. doi: 10.1128/AAC.01270-07. Epub 2008 Mar 31.

Abstract

Among 76 macrolide-nonsusceptible Streptococcus pneumoniae isolates collected between 2003 and 2005 from Central Russia, the resistance mechanisms detected in the isolates included erm(B) alone (50%), mef alone [mef(E), mef(I), or a different mef subclass; 19.7%], or both erm(B) and mef(E) (30.3%). Isolates with dual resistance genes [erm(B) and mef(E)] belonged to clonal complex CC81 or CC271.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Clindamycin / pharmacology
  • Drug Resistance, Bacterial / genetics*
  • Erythromycin / pharmacology
  • Humans
  • Macrolides / pharmacology*
  • Membrane Proteins / genetics
  • Methyltransferases / genetics
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Phenotype
  • Pneumococcal Infections / epidemiology
  • Pneumococcal Infections / microbiology
  • Russia / epidemiology
  • Sequence Analysis, DNA
  • Streptococcus pneumoniae / classification
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics
  • Streptococcus pneumoniae / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Macrolides
  • MefA protein, Streptococcus
  • MefE protein, Streptococcus pneumoniae
  • Membrane Proteins
  • Clindamycin
  • Erythromycin
  • Methyltransferases

Associated data

  • GENBANK/EU486995
  • GENBANK/EU486997
  • GENBANK/EU486999
  • GENBANK/EU487001