Abstract
Among 76 macrolide-nonsusceptible Streptococcus pneumoniae isolates collected between 2003 and 2005 from Central Russia, the resistance mechanisms detected in the isolates included erm(B) alone (50%), mef alone [mef(E), mef(I), or a different mef subclass; 19.7%], or both erm(B) and mef(E) (30.3%). Isolates with dual resistance genes [erm(B) and mef(E)] belonged to clonal complex CC81 or CC271.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Clindamycin / pharmacology
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Drug Resistance, Bacterial / genetics*
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Erythromycin / pharmacology
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Humans
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Macrolides / pharmacology*
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Membrane Proteins / genetics
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Methyltransferases / genetics
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Phenotype
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Pneumococcal Infections / epidemiology
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Pneumococcal Infections / microbiology
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Russia / epidemiology
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Sequence Analysis, DNA
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Streptococcus pneumoniae / classification
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / genetics
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Streptococcus pneumoniae / isolation & purification
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Macrolides
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MefA protein, Streptococcus
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MefE protein, Streptococcus pneumoniae
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Membrane Proteins
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Clindamycin
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Erythromycin
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Methyltransferases
Associated data
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GENBANK/EU486995
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GENBANK/EU486997
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GENBANK/EU486999
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GENBANK/EU487001