[Discovery, clinical and etiological characteristic of hemorrhagic fever with renal syndrome in the subtropical zone of Krasnodar region]

T K Dzagurova; E A Tkachenko; Iu V Iunicheva; V G Morozov; A F Briukhanov; V N Bashkirtsev; N S Sedova; B Klempa; D Kruger

[Discovery, clinical and etiological characteristic of hemorrhagic fever with renal syndrome in the subtropical zone of Krasnodar region]

Zh Mikrobiol Epidemiol Immunobiol. 2008 Jan-Feb:(1):12-6.

[Article in Russian]

Authors

T K Dzagurova, E A Tkachenko, Iu V Iunicheva, V G Morozov, A F Briukhanov, V N Bashkirtsev, N S Sedova, B Klempa, D Kruger

PMID: 18376466

Abstract

Twenty-six patients with hemorrhagic fever with renal syndrome (HFRS) were revealed as a result of serological examination of 582 patients with fever living around Sochi town. Etiologic role of Dobrava virus subtype as the cause of HFRS was assessed by immunofluorescent and ELISA assays, and neutralization test. The principal host of this virus and source of infection for humans is Caucasian forest mouse Apodemus ponticus. HFRS morbidity was sporadic and not dependent from patients' occupation and season. Comparative analysis of clinical and laboratory data from HFRS cases caused by DOB/Sochi and DOB/Lipetsk subspecies, as well as Puumala virus showed higher proportion of severe forms of disease in patients with HFRS from Sochi.

Publication types

English Abstract

MeSH terms

Animals
Antibodies, Viral / blood*
Diagnosis, Differential
Disease Reservoirs
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Hantaan virus / classification
Hantaan virus / immunology*
Hemorrhagic Fever with Renal Syndrome / blood
Hemorrhagic Fever with Renal Syndrome / diagnosis
Hemorrhagic Fever with Renal Syndrome / epidemiology*
Humans
Murinae
Neutralization Tests
Russia / epidemiology
Seroepidemiologic Studies

Substances

Antibodies, Viral