Most phytoviruses rely on vectors for their spread and survival. Although a great variety of virus vectors have been described, there are relatively few different mechanisms mediating virus transmission by vectors: virions can either be internalized into vector cells where replication may or may not take place or they can simply be adsorbed on the vector's surface or cuticle. Virus transmission by vectors requires tight associations between viral proteins, generally capsid proteins, and vector compounds, usually referred to as receptors. This review will focus on the viral determinants involved in virus transmission. Only the best-known models for which molecular data are available are described.