Inhibition and dispersion of proteobacterial biofilms

Justin J Richards; Robert W Huigens Iii; T Eric Ballard; Anne Basso; John Cavanagh; Christian Melander

doi:10.1039/b719802g

Inhibition and dispersion of proteobacterial biofilms

Chem Commun (Camb). 2008 Apr 14:(14):1698-700. doi: 10.1039/b719802g. Epub 2008 Feb 8.

Authors

Justin J Richards¹, Robert W Huigens Iii, T Eric Ballard, Anne Basso, John Cavanagh, Christian Melander

Affiliation

¹ North Carolina State University, Department of Chemistry, Raleigh, North Carolina 27695-8204, USA.

PMID: 18368169
DOI: 10.1039/b719802g

Abstract

A small molecule derived from a marine natural product with the ability to inhibit biofilm formation and also disperse established proteobacterial biofilms is presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biofilms / drug effects*
Biofilms / growth & development
Dose-Response Relationship, Drug
Imidazoles / chemistry
Imidazoles / pharmacology*
Inhibitory Concentration 50
Molecular Structure
Proteobacteria / drug effects*
Proteobacteria / growth & development
Proteobacteria / physiology
Pyrroles / chemistry
Pyrroles / pharmacology*

Substances

Imidazoles
Pyrroles
dihydrosventrin