Abstract
Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Caffeine / chemistry*
-
Crystallization
-
Crystallography, X-Ray
-
Drug Stability*
-
Hydrogen Bonding
-
Malates / chemistry*
-
Molecular Structure
-
Stereoisomerism
-
Tartrates / chemistry*
-
Theophylline / chemistry*
-
Water / chemistry
Substances
-
Malates
-
Tartrates
-
Water
-
Caffeine
-
malic acid
-
Theophylline
-
tartaric acid