Abstract
A small library of 2,2'-[(alpha,omega-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives emerged as promising hits characterized by IC(50) values lower than that determined for pentamidine against L. donovani.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemical synthesis*
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / pharmacology*
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Bisbenzimidazole / chemical synthesis*
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Bisbenzimidazole / chemistry
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Bisbenzimidazole / pharmacology*
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Leishmania donovani / drug effects
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Molecular Structure
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Pneumocystis carinii / drug effects
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Structure-Activity Relationship
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Trypanosoma brucei brucei / drug effects
Substances
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Antiprotozoal Agents
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Bisbenzimidazole