Abstract
In recent years, alendronate, an oral biphosphonate, has been added to therapy of hypercalcemia secondary to vitamin D intoxication in children. Alendronate may cause mucosal ulcerations in the mouth and esophagus. We report our experience in two infants with vitamin D intoxication to whom alendronate therapy was administered through nasogastric tube, an alternate route for alendronate administration.
MeSH terms
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Alendronate / therapeutic use*
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Bone Density Conservation Agents / therapeutic use*
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Drug Overdose
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Female
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Humans
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Hypercalcemia / chemically induced
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Hypercalcemia / diagnosis
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Hypercalcemia / drug therapy*
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Infant
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Intubation, Gastrointestinal
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Male
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Nephrocalcinosis / chemically induced
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Nephrocalcinosis / diagnosis
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Nephrocalcinosis / drug therapy*
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Treatment Outcome
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Vitamin D / poisoning*
Substances
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Bone Density Conservation Agents
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Vitamin D
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Alendronate