Intragastric alendronate therapy in two infants with vitamin D intoxication: a new method

Clin Toxicol (Phila). 2008 Apr;46(4):300-2. doi: 10.1080/15563650701455361.

Abstract

In recent years, alendronate, an oral biphosphonate, has been added to therapy of hypercalcemia secondary to vitamin D intoxication in children. Alendronate may cause mucosal ulcerations in the mouth and esophagus. We report our experience in two infants with vitamin D intoxication to whom alendronate therapy was administered through nasogastric tube, an alternate route for alendronate administration.

Publication types

  • Case Reports

MeSH terms

  • Alendronate / therapeutic use*
  • Bone Density Conservation Agents / therapeutic use*
  • Drug Overdose
  • Female
  • Humans
  • Hypercalcemia / chemically induced
  • Hypercalcemia / diagnosis
  • Hypercalcemia / drug therapy*
  • Infant
  • Intubation, Gastrointestinal
  • Male
  • Nephrocalcinosis / chemically induced
  • Nephrocalcinosis / diagnosis
  • Nephrocalcinosis / drug therapy*
  • Treatment Outcome
  • Vitamin D / poisoning*

Substances

  • Bone Density Conservation Agents
  • Vitamin D
  • Alendronate