Abstract
Fractionation of the ethanolic extract of the stem bark of Morus yunanensis resulted in the isolation of a new Diels-Alder type adduct and two new flavones, named yunanensin A (1), yunanensol A (2) and yunanensol B (3), respectively, together with a known flavone (4). Their structures were determined on the basis of spectroscopic analysis and chemical methods. Among them, compound 1 showed moderate antioxidant and significant cytotoxic activities, and compound 2 showed potent anti-inflammatory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Cell Line
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Cell Line, Tumor
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Cell Survival / drug effects
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Flavones / chemistry
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Flavones / isolation & purification*
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Flavones / pharmacology
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Inhibitory Concentration 50
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Microsomes, Liver / drug effects
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Morus / chemistry*
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Neutrophils
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Nuclear Magnetic Resonance, Biomolecular
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Optical Rotation
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Plant Bark / chemistry
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Rats
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Antioxidants
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Flavones