Photo-onycholysis caused by olanzapine and aripiprazole

J Clin Psychopharmacol. 2008 Apr;28(2):219-20. doi: 10.1097/JCP.0b013e318166c50a.

Abstract

Photo-onycholysis associated with drugs is an uncommon disorder. We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine. Substitution of olanzapine with aripiprazole further exacerbated the problem. The possible mechanisms of photo-onycholysis development by modern atypical antipsychotics, modulating dopamine receptors, are discussed.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use
  • Aripiprazole
  • Benzodiazepines / adverse effects*
  • Benzodiazepines / therapeutic use
  • Bipolar Disorder / drug therapy
  • Erythema / chemically induced
  • Erythema / diagnosis
  • Female
  • Humans
  • Middle Aged
  • Olanzapine
  • Onycholysis / chemically induced*
  • Onycholysis / diagnosis
  • Photosensitivity Disorders / chemically induced*
  • Photosensitivity Disorders / diagnosis
  • Piperazines / adverse effects*
  • Piperazines / therapeutic use
  • Quinolones / adverse effects*
  • Quinolones / therapeutic use

Substances

  • Antipsychotic Agents
  • Piperazines
  • Quinolones
  • Benzodiazepines
  • Aripiprazole
  • Olanzapine