[External radiotherapy and photodynamic therapy for esophageal carcinoma: a dangerous association?]

Gastroenterol Clin Biol. 2008 Mar;32(3):221-3. doi: 10.1016/j.gcb.2007.08.001. Epub 2008 Mar 14.
[Article in French]

Abstract

A 60-year-old man presented an oesophageal transmural necrosis fistulised in the trachea following curative photodynamic therapy (PDT) for a superficial recurrence of an oesophageal carcinoma, initially treated by radiochemotherapy. Two stents, a tracheal and an oesophageal one, were placed. Eight months later the patient is in complete remission with only mild swallowing problems. This complication, although unusual, has already been described by other teams with the association of radiochemotherapy and PDT. The present case study suggests that illumination dose should be lowered in this indication.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Carcinoma, Squamous Cell / therapy
  • Chemotherapy, Adjuvant
  • Dihematoporphyrin Ether / adverse effects
  • Esophageal Neoplasms / therapy*
  • Humans
  • Male
  • Middle Aged
  • Necrosis
  • Neoplasm Recurrence, Local / drug therapy*
  • Photochemotherapy / adverse effects*
  • Photosensitizing Agents / adverse effects
  • Radiotherapy, Adjuvant
  • Stents
  • Tracheoesophageal Fistula / etiology*
  • Tracheoesophageal Fistula / pathology
  • Tracheoesophageal Fistula / surgery

Substances

  • Photosensitizing Agents
  • Dihematoporphyrin Ether