Abstract
In a recent issue of Cell Host & Microbe, Kwon et al. (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation.
MeSH terms
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Acquired Immunodeficiency Syndrome / immunology
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Animals
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HIV-1 / genetics
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HIV-1 / metabolism
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Humans
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Lymphocyte Activation
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Mice
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NF-kappa B / metabolism
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Sirtuin 1
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Sirtuins / genetics
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Sirtuins / metabolism*
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T-Lymphocytes / immunology
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Transcription, Genetic
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tat Gene Products, Human Immunodeficiency Virus / genetics
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tat Gene Products, Human Immunodeficiency Virus / metabolism*
Substances
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NF-kappa B
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tat Gene Products, Human Immunodeficiency Virus
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SIRT1 protein, human
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Sirtuin 1
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Sirtuins