Abstract
A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities.
MeSH terms
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / pharmacology*
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Aziridines / chemistry
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Azo Compounds / chemistry
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Bacteria / drug effects*
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Carbazoles
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Cyclization
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Fungi / drug effects*
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Humans
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Isatin / chemistry
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Microbial Sensitivity Tests
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Models, Chemical
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Plants / drug effects*
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Plants / microbiology
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Proline / chemistry
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Pyrrolizidine Alkaloids / chemical synthesis
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Pyrrolizidine Alkaloids / pharmacology*
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Spiro Compounds / chemical synthesis
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Spiro Compounds / pharmacology*
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Thiosemicarbazones / chemistry
Substances
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Anti-Infective Agents
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Aziridines
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Azo Compounds
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Carbazoles
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Pyrrolizidine Alkaloids
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Spiro Compounds
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Thiosemicarbazones
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azomethine
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Isatin
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Proline