Investigation on the effect of eclipta alba on animal models of learning and memory

Indian J Physiol Pharmacol. 2007 Jul-Sep;51(3):274-8.

Abstract

Short and long term memory loss may result from deteriorating cerebral mechanisms due to varied causes which could have a tremendous impact on the quality of life. Herbs are being constantly explored to resolve cognitive deficits. Eclipta alba (Ea) commonly called as the trailing Eclipta is being examined for its memory enhancing quality as it is traditionally used for this purpose. The shade dried leaves of Eclipta alba was extracted with distilled water. The suspension of Ea containing 100 and 200 mg/kg was administered to rats to evaluate Transfer Latency (TL) on an elevated plus maze. TL was a measure of acquisition and retrieval learning. Mice were placed at the center of open field apparatus to assess spatial habitual learning, observed for 20 minutes for rearing and time spent during rearing using varied doses for 30 minutes, 24 hours and 96 hours and 144 hrs. The results revealed significant improvement of retrieval memory.

MeSH terms

  • Administration, Oral
  • Animals
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology
  • Dose-Response Relationship, Drug
  • Eclipta / chemistry*
  • Maze Learning / drug effects*
  • Maze Learning / physiology
  • Memory / drug effects*
  • Memory / physiology
  • Mice
  • Models, Animal
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Rats
  • Rats, Wistar
  • Space Perception / drug effects
  • Space Perception / physiology
  • Spatial Behavior / drug effects
  • Spatial Behavior / physiology
  • Time Factors
  • Transfer, Psychology / drug effects
  • Transfer, Psychology / physiology

Substances

  • Plant Extracts