Prevalence and genotypes identification of human papillomavirus infection in a population of South Italy

J Clin Virol. 2008 Jun;42(2):211-4. doi: 10.1016/j.jcv.2008.01.011. Epub 2008 Mar 14.

Abstract

Background: A limited number of human papillomavirus (HPV) types account for the majority of invasive cervical cancer cases.

Objectives: To assess, in a southern Italian region, where HPV infection had not yet been investigated, the prevalence of type-specific HPV infection.

Study design: Multiplex PCR was used to test cervical specimens from 871 asymptomatic women.

Results: The HPV infection rate was 23.1%, with the highest prevalence being observed in women aged 20-30 years (32.6%). Type 16 was the most frequent HPV type detected either in mono-infected (39.8%) or in multi-infected (46.3%) women.

Conclusions: The HPV infection rate was higher than reported from other Italian areas. Our results further emphasise the importance of vaccinations to immunize females before they acquire HPV infection.

MeSH terms

  • Adult
  • Colposcopy
  • DNA, Viral / analysis
  • DNA, Viral / isolation & purification
  • Female
  • Genotype
  • Humans
  • Italy / epidemiology
  • Middle Aged
  • Papillomaviridae / classification*
  • Papillomaviridae / genetics
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / virology
  • Polymerase Chain Reaction / methods
  • Prevalence
  • Vaginal Smears

Substances

  • DNA, Viral