Abstract
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Protozoan / chemistry*
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Antigen-Antibody Reactions
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Antigens, Protozoan / chemistry*
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Antigens, Protozoan / immunology
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Carbohydrate Conformation
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Glycosylphosphatidylinositols / chemistry*
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Glycosylphosphatidylinositols / immunology
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Humans
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Malaria / immunology
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Malaria Vaccines / chemical synthesis
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Malaria Vaccines / chemistry*
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Malaria Vaccines / immunology
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Microarray Analysis / methods*
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Molecular Sequence Data
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Plasmodium falciparum / immunology
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Polysaccharides / chemical synthesis
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Polysaccharides / chemistry*
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Polysaccharides / immunology
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Reproducibility of Results
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Sensitivity and Specificity
Substances
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Antibodies, Protozoan
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Antigens, Protozoan
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Glycosylphosphatidylinositols
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Malaria Vaccines
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Polysaccharides
Associated data
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PubChem-Substance/47213182
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PubChem-Substance/47213183
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PubChem-Substance/47213184
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PubChem-Substance/47213185
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PubChem-Substance/47213186
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PubChem-Substance/47213187
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PubChem-Substance/47213188