Three new nardosinane Type Sesquiterpenes from an Indonesian Soft Coral Nephthea sp

Chem Pharm Bull (Tokyo). 2008 Mar;56(3):332-4. doi: 10.1248/cpb.56.332.

Abstract

Three new sesquiterpenes, 2-deoxy-7-O-methyllemnacarnol (1), 2-deoxy-12 alpha-ethoxy-7-O-methyllemnacarnol (2), and 2-deoxy-12 alpha-methoxy-7-O-methyllemnacarnol (3), were isolated from a soft coral Nephthea sp. collected in Indonesia, together with five known sesquiterpenes. The structures of the new compounds were assigned on the basis of their spectroscopic data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Cell Proliferation / drug effects
  • Cricetinae
  • Cricetulus
  • Indonesia
  • Leukemia P388 / drug therapy
  • Magnetic Resonance Spectroscopy
  • Mice
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • 2-deoxy-12 alpha-ethoxy-7-O-methyllemnacarnol
  • 2-deoxy-12 alpha-methoxy-7-O-methyllemnacarnol
  • 2-deoxy-7-O-methyllemnacarnol
  • Antineoplastic Agents
  • Sesquiterpenes