Abstract
We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.
MeSH terms
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Chromosome Aberrations*
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Complementarity Determining Regions / genetics*
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Humans
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Immunoglobulin G / genetics*
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Immunoglobulin Switch Region
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Leukemia, Lymphocytic, Chronic, B-Cell / classification
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Leukemia, Lymphocytic, Chronic, B-Cell / immunology
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Neoplasm Proteins / genetics*
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Receptors, Antigen, B-Cell / genetics*
Substances
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Complementarity Determining Regions
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Immunoglobulin G
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Neoplasm Proteins
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Receptors, Antigen, B-Cell