Autoimmunity and celiac disease

Mini Rev Med Chem. 2008 Feb;8(2):129-34. doi: 10.2174/138955708783498113.

Abstract

In celiac disease (CD), abnormal immune-mediated responses follow ingestion of gluten. Although the triggering agent is a dietary protein, the disease has autoimmune components because of the presence of autoantibodies and its association with autoimmune conditions. We review the most recent studies on CD pathogenesis and the possibilities to modulate immune dysfunction in CD.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Autoimmunity / immunology*
  • Celiac Disease / drug therapy
  • Celiac Disease / genetics
  • Celiac Disease / immunology*
  • Celiac Disease / metabolism
  • Epithelial Cells / immunology
  • Epithelial Cells / pathology
  • GTP-Binding Proteins
  • Glutens / chemistry
  • Glutens / immunology
  • Glutens / metabolism
  • Humans
  • Immunity, Innate
  • Molecular Sequence Data
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases / immunology

Substances

  • Glutens
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases
  • GTP-Binding Proteins