The present review is intended to give an outlook on the relationship between male reproduction and seminal vesicles, which are an important subsidiary gonad of males and play a key role in male fertility process. Seminal vesicle secretion is important for semen coagulation and may promote sperm motility, increase stability of sperm chromatin, and suppress the immune activity in the female reproductive tract. Furthermore, the sexual function of males is closely related to the swelling degree of seminal vesicles. The abnormal function of seminal vesicles may give rise to sexual dysfunction and infertility of males.