Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany

Fertil Steril. 2009 Jan;91(1):125-32. doi: 10.1016/j.fertnstert.2007.11.030. Epub 2008 Feb 20.

Abstract

Objective: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI).

Design: Prospective controlled blinded study.

Setting: Tertiary care center.

Patient(s): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years.

Main outcome measure(s): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children.

Result(s): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence.

Conclusion(s): The ICSI children born at term develop normally, similar to SC children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child Development / physiology*
  • Child, Preschool
  • Emotions
  • Female
  • Germany
  • Humans
  • Intelligence
  • Longitudinal Studies
  • Male
  • Mental Health*
  • Motor Skills / physiology*
  • Patient Selection
  • Pregnancy
  • Prospective Studies
  • Single-Blind Method
  • Sperm Injections, Intracytoplasmic / methods
  • Sperm Injections, Intracytoplasmic / statistics & numerical data*