Objective: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI).
Design: Prospective controlled blinded study.
Setting: Tertiary care center.
Patient(s): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years.
Main outcome measure(s): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children.
Result(s): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence.
Conclusion(s): The ICSI children born at term develop normally, similar to SC children.