Abstract
Two geminal difluorosteroids, 3,3-difluoro-5beta-cholan-24-oic acid (1) and 3,3-difluoro-5alpha-androstan-17-one (2), have been prepared from corresponding ketosteroids with diethylaminosulphurtrifluoride (DAST) treatment in moderate yields. The structures of 1 and 2 have been characterized by (1)H, (13)C, (19)F NMR, and ESI mass spectral techniques.
Copyright (c) 2008 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Androstanes / chemical synthesis
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Androstanes / chemistry*
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Carbon Isotopes
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Fluorine / chemistry*
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Magnetic Resonance Spectroscopy / methods*
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Magnetic Resonance Spectroscopy / standards
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Molecular Conformation
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Protons
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Reference Standards
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Spectrometry, Mass, Electrospray Ionization / methods*
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Stereoisomerism
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Steroids / chemical synthesis
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Steroids / chemistry*
Substances
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3,3-difluoro-5alpha-androstan-17-one
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3,3-difluoro-5beta-cholan-24-oic acid
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Androstanes
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Carbon Isotopes
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Protons
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Steroids
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Fluorine