Two new bioactive prenylated dihydroflavanoids from the medicinal plant Dolichos tenuicaulis (Baker) Craib

J Asian Nat Prod Res. 2008 Jan-Feb;10(1-2):169-75. doi: 10.1080/10286020701394340.

Abstract

Two new prenylated dihydroflavanoids have been isolated from the medicinal plant of Dolichos tenuicaulis (Baker) Craib. Their structures were elucidated as (2S)-5,2',6'-trihydroxy-8-prenyl-6,7-(3-prenyl-2,2-dimethylpyrano)-3',4'-(2,2-dimethyl-1-keone-cyclohexadiene)-flavanone (1) and (2S)-5,2',6'-trihydroxy-8-prenyl-6,7-(3-prenyl-2,2-dimethyl-1-keone-cyclohexadiene)-flavanone (2) on the basis of spectroscopic analysis.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Cyclohexenes / chemistry*
  • Cyclohexenes / pharmacology*
  • Dolichos / chemistry*
  • Flavanones / chemistry*
  • Flavanones / pharmacology*
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology*
  • Humans
  • Molecular Structure
  • Neoplasms / drug therapy
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*

Substances

  • (2S)-5,2',6'-trihydroxy-8-prenyl-6,7-(3-prenyl-2,2-dimethyl-1-keone-cyclohexadiene)-flavanone
  • (2S)-5,2',6'-trihydroxy-8-prenyl-6,7-(3-prenyl-2,2-dimethylpyrano)-3',4'-(2,2-dimethyl-1-keone-cyclohexadiene)-flavanone
  • Antineoplastic Agents, Phytogenic
  • Cyclohexenes
  • Flavanones
  • Flavonoids