Abstract
Three novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium minioluteum strain. Their structures were determined by NMR spectroscopic analyses and X-ray crystallography. The proposed biosynthetic pathway including a unique retro-Claisen migration of methyl carbonate correlates the three compounds with berkeleydione and berkeleytrione.
MeSH terms
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Crystallography, X-Ray
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Methicillin Resistance / drug effects
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Penicillium / chemistry*
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Staphylococcus aureus / drug effects
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Terpenes / isolation & purification*
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Terpenes / pharmacology
Substances
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22-epoxyberkeleydione
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Macrolides
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Terpenes
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berkeleydione
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berkeleytrione
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miniolutelide A
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miniolutelide B