Abstract
tert-Alkyl amino hydroxy carboxylic acids are abundantly present within the structure of many biologically active natural products. We describe herein the synthesis of these substrates using an oxazolone-mediated ene-type reaction with enol ethers followed by NaBH4 reduction of the intermediate oxazolone.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemical synthesis*
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Carboxylic Acids / chemical synthesis*
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Crystallography, X-Ray
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Esters
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Ethers / chemistry*
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Ketones / chemistry*
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Molecular Conformation
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Molecular Structure
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Oxazolone / analogs & derivatives*
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Oxazolone / chemistry*
Substances
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Alkynes
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Carboxylic Acids
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Esters
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Ethers
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Ketones
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Oxazolone