Abstract
The first therapeutic aptamer was approved for human use in 2004, and a range of chemical substitutions that improve the drug-like properties of aptamers has recently been shown to increase the utility of this modality. Currently there are both anticoagulant and antithrombotic aptamers in the clinic, and additionally there are a number of earlier stage projects in which a variety of cardiovascular targets are inhibited by specific aptamers and for which a wide range of therapeutic applications has been suggested.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anticoagulants / pharmacology
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Aptamers, Nucleotide / pharmacology*
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Aptamers, Nucleotide / therapeutic use
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Cardiovascular Agents / pharmacology*
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Cardiovascular Agents / therapeutic use
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Cardiovascular Diseases / drug therapy*
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Cardiovascular Diseases / physiopathology
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Cell Adhesion / drug effects
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Drug Delivery Systems
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Fibrinolytic Agents / pharmacology
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Humans
Substances
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Anticoagulants
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Aptamers, Nucleotide
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Cardiovascular Agents
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Fibrinolytic Agents