Abstract
Although anti- angiogenesis strategies have generated much enthusiasm for therapeutic applications, it is still unknown whether they would be feasible for prevention. The possibility of interfering very early in tumor progression by modulating the cancer angiogenic switch is appealing. In this chapter, we review progress with in vitro and in vivo models that show that anti-angiogenic interventions may be amenable to long- term chemopreventive measures. In particular, some approaches that are nearly ready for major applications are anti-oxidant nutraceuticals and copper deficiency. We use these strategies as paradigms of how to make progress in this difficult but important area of translational research.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Angiogenesis Inhibitors / pharmacology*
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Angiogenesis Inhibitors / therapeutic use
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Animals
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Anticarcinogenic Agents / pharmacology*
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Anticarcinogenic Agents / therapeutic use
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Antioxidants / pharmacology*
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Antioxidants / therapeutic use
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Breast Neoplasms / metabolism
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Breast Neoplasms / prevention & control
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Carotenoids / pharmacology
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Cell Transformation, Neoplastic / drug effects
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Chelating Agents / pharmacology*
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Chelating Agents / therapeutic use
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Copper / deficiency
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Copper / metabolism*
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Dietary Supplements*
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Female
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Flavonoids / pharmacology
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Head and Neck Neoplasms / metabolism
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Head and Neck Neoplasms / prevention & control
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Humans
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Lung Neoplasms / metabolism
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Lung Neoplasms / prevention & control
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Male
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Molybdenum / pharmacology
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NF-kappa B / metabolism
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Neoplasms / blood supply
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Neoplasms / metabolism
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Neoplasms / prevention & control*
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Neovascularization, Pathologic / metabolism
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Neovascularization, Pathologic / prevention & control*
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Phenols / pharmacology
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Polyphenols
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Prostatic Neoplasms / metabolism
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Prostatic Neoplasms / prevention & control
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Reactive Oxygen Species / metabolism
Substances
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Angiogenesis Inhibitors
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Anticarcinogenic Agents
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Antioxidants
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Chelating Agents
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Flavonoids
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NF-kappa B
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Phenols
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Polyphenols
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Reactive Oxygen Species
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Carotenoids
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Copper
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Molybdenum
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tetrathiomolybdate