A discrete view on fold space

Manfred J Sippl; Stefan J Suhrer; Markus Gruber; Markus Wiederstein

doi:10.1093/bioinformatics/btn020

A discrete view on fold space

Bioinformatics. 2008 Mar 15;24(6):870-1. doi: 10.1093/bioinformatics/btn020. Epub 2008 Jan 24.

Authors

Manfred J Sippl¹, Stefan J Suhrer, Markus Gruber, Markus Wiederstein

Affiliation

¹ Center of Applied Molecular Engineering, Division of Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstr. 34, 5020 Salzburg, Austria. sippl@came.sbg.ac.at

PMID: 18218654
DOI: 10.1093/bioinformatics/btn020

Abstract

The database of known protein structures contains an overwhelming number of structural similarities that frequently point to intriguing biological relationships. The similarities are often difficult to spot, and once detected their comprehension needs proper visualization. Here we introduce the new concept of a Fold Space Navigator, a user interface enabling the efficient navigation through fold space and the instantaneous visualization of pairwise structure similarities.

Availability: The Fold Space Navigator is accessible as a public web service at http://services.came.sbg.ac.at

MeSH terms

Algorithms
Amino Acid Sequence
Computer Simulation
Databases, Protein*
Information Storage and Retrieval / methods
Models, Chemical*
Models, Molecular*
Molecular Sequence Data
Protein Folding
Proteins / chemistry*
Proteins / ultrastructure*
Sequence Analysis, Protein / methods
Software*
User-Computer Interface*

Substances

Proteins