Synthesis and biological activity of chloroethyl pyrimidine nucleosides

Ludovic Colombeau; Karine Teste; Amel Hadj-Bouazza; Vincent Chaleix; Rachida Zerrouki; Michel Kraemer; Odile Sainte Catherine

doi:10.1080/15257770701795813

Synthesis and biological activity of chloroethyl pyrimidine nucleosides

Nucleosides Nucleotides Nucleic Acids. 2008 Feb;27(2):110-20. doi: 10.1080/15257770701795813.

Authors

Ludovic Colombeau¹, Karine Teste, Amel Hadj-Bouazza, Vincent Chaleix, Rachida Zerrouki, Michel Kraemer, Odile Sainte Catherine

Affiliation

¹ Université de Limoges, Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Limoges, France.

PMID: 18205066
DOI: 10.1080/15257770701795813

Abstract

The synthesis and biological activity of chloroethyl pyrimidine nucleosides is presented. One of these new nucleosides analogues significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Carcinoma, Squamous Cell / drug therapy
Cell Line, Tumor
Cell Movement / drug effects
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Female
Humans
Hydrocarbons, Chlorinated / chemical synthesis*
Hydrocarbons, Chlorinated / chemistry
Hydrocarbons, Chlorinated / pharmacology
Pyrimidine Nucleosides / chemical synthesis*
Pyrimidine Nucleosides / chemistry
Pyrimidine Nucleosides / pharmacology
Vulvar Neoplasms / drug therapy

Substances

Antineoplastic Agents
Hydrocarbons, Chlorinated
Pyrimidine Nucleosides