Oxygenated cembranoids from a Formosan soft coral Sinularia gibberosa

J Nat Prod. 2008 Feb;71(2):179-85. doi: 10.1021/np070356p. Epub 2008 Jan 17.

Abstract

Chemical investigation of a Formosan soft coral, Sinularia gibberosa, has led to the isolation of eight oxygenated cembranoids, 1- 8, including seven new compounds, gibberosenes A-G ( 2- 8). None of these compounds were found to be cytotoxic toward a limited panel of cancer cell lines. Compound 1 significantly inhibited the accumulation of the pro-inflammatory COX-2 protein of the LPS-stimulated RAW264.7 macrophage cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Carboxypeptidases
  • Carboxypeptidases A / drug effects
  • Carboxypeptidases A / metabolism
  • Computer Simulation
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Mice
  • Molecular Structure
  • Oxygen / chemistry
  • Taiwan

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Diterpenes
  • Lipopolysaccharides
  • Carboxypeptidases
  • Cpxm2 protein, mouse
  • Carboxypeptidases A
  • Oxygen