Progestogen is a very important steroid hormone which has roles of supporting pregnancy secreted from ovary and placenta. From 1930, a lot of progestogens are compounded for clinical use. Compounded progestogens have not only progesterone effect but also estrogen, androgen and corticosteroid effects, respectively. Progestogen is used for treatment of hormone therapy of ovulation disorders. In recent clinical application, progestogens have some important effects in contraceptives, endometriosis and hormone replacement therapy.