Abstract
Using a series of efflux mutants of Pseudomonas aeruginosa, the MexAB-OprM pump was identified as contributing to this organism's tolerance to the antimicrobial agent tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol. These data show that a multidrug efflux system of P. aeruginosa can extrude monoterpenes and related alcohols.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / physiology*
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Cyclohexane Monoterpenes
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Cyclohexanols / chemistry
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Cyclohexanols / pharmacology
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Cyclohexenes / chemistry
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Cyclohexenes / pharmacology
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Eucalyptol
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Melaleuca / chemistry*
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Membrane Transport Proteins / genetics
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Membrane Transport Proteins / physiology
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Monoterpenes / chemistry
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Monoterpenes / pharmacology*
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Mutation
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / growth & development
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Tea Tree Oil / chemistry
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Tea Tree Oil / pharmacology*
Substances
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Bacterial Outer Membrane Proteins
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Cyclohexane Monoterpenes
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Cyclohexanols
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Cyclohexenes
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Membrane Transport Proteins
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MexA protein, Pseudomonas aeruginosa
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MexB protein, Pseudomonas aeruginosa
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Monoterpenes
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OprM protein, Pseudomonas aeruginosa
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alpha-terpineol
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Tea Tree Oil
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Eucalyptol