A 38-year-old male presented with a slowly progressive and painful swelling in the right cheek. On palpation, a firm, fixed and tender mass was detected over the right maxilla, with normal overlying skin. Endoscopic examination revealed a submucosal mass protruding into the right nasal cavity along the lateral wall, extending from the vestibule to the sphenoid sinus. Computed tomography showed a well-defined, 4x4 cm mass with cystic compartments, obliterating the right maxillary sinus, with destruction to the medial wall and extension into the nasal cavity. Magnetic resonance imaging showed similar findings of extension. A transnasal biopsy yielded a diagnosis of myxoma. En bloc resection of the mass was performed through a medial maxillectomy. No clinical or radiological recurrences were noted during a follow-up period of 24 months.