A new leishmanicidal saponin from Brunfelsia grandiflora

Chem Pharm Bull (Tokyo). 2008 Jan;56(1):93-6. doi: 10.1248/cpb.56.93.

Abstract

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O-beta-D-glucopyranosyl 22alpha-methoxyfurost-3beta,26-diol 3-O-beta-D-xylopyranosyl(1-->3)-{beta-D-glucopyranosyl(1-->2)}-beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / isolation & purification*
  • Antiprotozoal Agents / pharmacology*
  • Leishmania major / drug effects*
  • Leishmaniasis, Cutaneous / drug therapy*
  • Molecular Structure
  • Peru
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology*
  • Solanaceae / chemistry*

Substances

  • 26-O-beta-D-glucopyranosyl 22alpha-methoxyfurost-3beta,26-diol 3-O-beta-D-xylopyranosyl(1-3)-(beta-D-glucopyranosyl(1-2))beta-D-glucopyranosyl(1-4)beta-D-glucopyranoside
  • Antiprotozoal Agents
  • Saponins