Abstract
A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O-beta-D-glucopyranosyl 22alpha-methoxyfurost-3beta,26-diol 3-O-beta-D-xylopyranosyl(1-->3)-{beta-D-glucopyranosyl(1-->2)}-beta-D-glucopyranosyl(1-->4)-beta-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification*
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Antiprotozoal Agents / pharmacology*
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Leishmania major / drug effects*
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Leishmaniasis, Cutaneous / drug therapy*
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Molecular Structure
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Peru
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology*
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Solanaceae / chemistry*
Substances
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26-O-beta-D-glucopyranosyl 22alpha-methoxyfurost-3beta,26-diol 3-O-beta-D-xylopyranosyl(1-3)-(beta-D-glucopyranosyl(1-2))beta-D-glucopyranosyl(1-4)beta-D-glucopyranoside
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Antiprotozoal Agents
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Saponins