Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis

Antimicrob Agents Chemother. 2008 Mar;52(3):1176-8. doi: 10.1128/AAC.01425-07. Epub 2007 Dec 26.

Abstract

Serum (1-->3)-beta-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Outbred Strains
  • Antifungal Agents / therapeutic use*
  • Aspergillosis* / diagnosis
  • Aspergillosis* / drug therapy
  • Aspergillosis* / microbiology
  • Aspergillosis* / mortality
  • Aspergillus fumigatus* / drug effects
  • Aspergillus fumigatus* / isolation & purification
  • Biomarkers / blood*
  • Disease Models, Animal
  • Humans
  • Lung / microbiology
  • Lung Diseases, Fungal* / diagnosis
  • Lung Diseases, Fungal* / drug therapy
  • Lung Diseases, Fungal* / microbiology
  • Lung Diseases, Fungal* / mortality
  • Mice
  • Mice, Inbred ICR
  • Proteoglycans
  • Treatment Outcome
  • beta-Glucans / blood*

Substances

  • Antifungal Agents
  • Biomarkers
  • Proteoglycans
  • beta-Glucans
  • polysaccharide-K