Abstract
A series of fluorenyl analogues of verapamil were synthesized and their cardiovascular properties on guinea pig isolated atria and isolated perfused heart evaluated. The compounds were also tested for their calcium antagonistic activity on guinea pig aorta. They were found to be poor calcium antagonists, but showed negative inotropic and antiarrhythmic properties. The results obtained seem to indicate that their mechanism of action differs from that of verapamil.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Arrhythmia Agents / chemical synthesis
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Anti-Arrhythmia Agents / pharmacology
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Aorta, Thoracic / drug effects
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Calcium Channel Blockers / chemical synthesis
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Calcium Channel Blockers / pharmacology
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Cardiovascular Agents / chemical synthesis*
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Cardiovascular Agents / pharmacology
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Electrocardiography / drug effects
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Female
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Fluorenes / chemical synthesis*
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Fluorenes / pharmacology
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Guinea Pigs
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Heart / drug effects
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Heart Rate / drug effects
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Hemodynamics / drug effects*
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In Vitro Techniques
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Male
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects
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Perfusion
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Sinoatrial Node / drug effects
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Verapamil / analogs & derivatives*
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Verapamil / chemical synthesis*
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Verapamil / pharmacology
Substances
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Anti-Arrhythmia Agents
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Calcium Channel Blockers
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Cardiovascular Agents
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Fluorenes
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Verapamil