Neurobiological substrates of electroconvulsive therapy for Tourette syndrome: a Serial SISCOM study

J ECT. 2007 Dec;23(4):278-80. doi: 10.1097/YCT.0b013e31811f354c.

Abstract

We report the case of an adult male patient with Tourette syndrome, self-injurious behavior and depression, refractory to conventional treatment, and whose symptoms remitted after electroconvulsive therapy. Serial Technetium 99m-Ethyl-Cysteinate-Dimer single photon emission tomographies were applied, before, during, and after electroconvulsive therapy. The neural substrates of this treatment process were further analyzed by woxel-wise subtracted single photon emission tomography images.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / blood supply
  • Brain / diagnostic imaging*
  • Brain / physiopathology
  • Brain Mapping
  • Brief Psychiatric Rating Scale
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / physiopathology
  • Combined Modality Therapy
  • Cysteine / analogs & derivatives
  • Depressive Disorder / diagnostic imaging
  • Depressive Disorder / physiopathology
  • Depressive Disorder / therapy
  • Electroconvulsive Therapy*
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging*
  • Male
  • Neurologic Examination
  • Organotechnetium Compounds
  • Psychotropic Drugs / administration & dosage
  • Regional Blood Flow / physiology
  • Self-Injurious Behavior / diagnostic imaging
  • Self-Injurious Behavior / physiopathology
  • Self-Injurious Behavior / therapy
  • Subtraction Technique
  • Tomography, Emission-Computed, Single-Photon*
  • Tourette Syndrome / diagnostic imaging*
  • Tourette Syndrome / physiopathology
  • Tourette Syndrome / therapy*

Substances

  • Organotechnetium Compounds
  • Psychotropic Drugs
  • technetium Tc 99m bicisate
  • Cysteine