[Hyperphosphatasia and hypophosphatasia in childhood]

Orthopade. 2008 Jan;37(1):31-9. doi: 10.1007/s00132-007-1181-5.
[Article in German]

Abstract

The treatment of phosphate diabetes and hyperphosphatasia requires an interdisciplinary therapy concept between paediatricians and orthopaedic surgeons. The surgical challenge is the correction of the multiplanar bending deformities and the pathological fractures. Different techniques are discussed in the literature without an outstanding recommendation for a special approach. This contribution gives an overview of the published methods and discusses various surgical concepts in view of our own clinical experience.

Publication types

  • Case Reports
  • Comparative Study
  • Review

MeSH terms

  • Adolescent
  • Alkaline Phosphatase / blood
  • Bone Density Conservation Agents / administration & dosage
  • Bone Density Conservation Agents / therapeutic use
  • Calcitriol / administration & dosage
  • Calcitriol / therapeutic use
  • Calcium / blood
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • External Fixators
  • Familial Hypophosphatemic Rickets* / blood
  • Familial Hypophosphatemic Rickets* / diagnosis
  • Familial Hypophosphatemic Rickets* / diagnostic imaging
  • Familial Hypophosphatemic Rickets* / drug therapy
  • Familial Hypophosphatemic Rickets* / surgery
  • Female
  • Femur / surgery
  • Follow-Up Studies
  • Humans
  • Hypophosphatasia* / blood
  • Hypophosphatasia* / diagnosis
  • Hypophosphatasia* / genetics
  • Infant
  • Male
  • Orthopedic Procedures
  • Osteitis Deformans* / blood
  • Osteitis Deformans* / diagnosis
  • Osteitis Deformans* / diagnostic imaging
  • Osteitis Deformans* / surgery
  • Osteotomy / methods
  • Phosphates / administration & dosage
  • Phosphates / blood
  • Phosphates / therapeutic use
  • Radiography
  • Tibia / surgery
  • Time Factors

Substances

  • Bone Density Conservation Agents
  • Phosphates
  • Alkaline Phosphatase
  • Calcitriol
  • Calcium