Synthesis and inhibitory effect on fat accumulation of (-)-ternatin derivatives modified in the beta-OH-D-Leu(7) moiety

Org Biomol Chem. 2008 Jan 7;6(1):58-60. doi: 10.1039/b714710d. Epub 2007 Nov 22.

Abstract

An efficient synthesis of (-)-ternatin derivatives directed toward their SAR at the beta-OH-D-Leu(7) moiety and their biological activities against 3T3-L1 murine adipocytes are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / cytology
  • Adipocytes / drug effects*
  • Adipocytes / metabolism
  • Adiposity / drug effects
  • Animals
  • Anti-Obesity Agents / chemical synthesis
  • Anti-Obesity Agents / chemistry
  • Anti-Obesity Agents / pharmacology
  • Anti-Obesity Agents / toxicity
  • Cell Survival
  • Inhibitory Concentration 50
  • Leucine / analogs & derivatives*
  • Leucine / chemistry*
  • Mice
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology*
  • Oligopeptides / toxicity
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology*
  • Peptides, Cyclic / toxicity
  • Stereoisomerism

Substances

  • Anti-Obesity Agents
  • Oligopeptides
  • Peptides, Cyclic
  • ternatin heptapeptide
  • Leucine