Abstract
An efficient synthesis of (-)-ternatin derivatives directed toward their SAR at the beta-OH-D-Leu(7) moiety and their biological activities against 3T3-L1 murine adipocytes are described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Adipocytes / cytology
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Adipocytes / drug effects*
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Adipocytes / metabolism
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Adiposity / drug effects
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Animals
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Anti-Obesity Agents / chemical synthesis
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / pharmacology
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Anti-Obesity Agents / toxicity
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Cell Survival
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Inhibitory Concentration 50
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Leucine / analogs & derivatives*
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Leucine / chemistry*
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Mice
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry
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Oligopeptides / pharmacology*
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Oligopeptides / toxicity
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / pharmacology*
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Peptides, Cyclic / toxicity
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Stereoisomerism
Substances
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Anti-Obesity Agents
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Oligopeptides
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Peptides, Cyclic
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ternatin heptapeptide
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Leucine