Roadmap methods for protein folding

Methods Mol Biol. 2008:413:219-39. doi: 10.1007/978-1-59745-574-9_9.

Abstract

Protein folding refers to the process whereby a protein assumes its intricate three-dimensional shape. This chapter reviews a class of methods for studying the folding process called roadmap methods. The goal of these methods is not to predict the folded structure of a protein, but rather to analyze the folding kinetics. It is assumed that the folded state is known. Roadmap methods maintain a graph representation of sampled conformations. By analyzing this graph one can predict structure formation order, the probability of folding, and get a coarse view of the energy landscape.

Publication types

  • Review

MeSH terms

  • Animals
  • Computational Biology / methods
  • Humans
  • Kinetics
  • Protein Conformation*
  • Protein Folding*
  • Proteins / chemistry
  • Thermodynamics

Substances

  • Proteins