The microbicide tenofovir does not inhibit nucleic acid amplification tests for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine samples

J Clin Microbiol. 2008 Feb;46(2):763-5. doi: 10.1128/JCM.01867-07. Epub 2007 Dec 5.

Abstract

The potential inhibitory effects of tenofovir and a placebo were examined using the Becton Dickinson ProbeTec, Gen-Probe Aptima Combo 2, and Roche Amplicor tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae. Concentrations of 5% to 0% of tenofovir and the placebo were added to dilutions of C. trachomatis and N. gonorrhoeae. No appreciable inhibition was observed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Anti-Infective Agents / pharmacology
  • Chlamydia Infections / diagnosis
  • Chlamydia trachomatis / genetics
  • Chlamydia trachomatis / isolation & purification*
  • Female
  • Gonorrhea / diagnosis
  • Humans
  • Male
  • Neisseria gonorrhoeae / genetics
  • Neisseria gonorrhoeae / isolation & purification*
  • Nucleic Acid Amplification Techniques / methods*
  • Organophosphonates / pharmacology*
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Tenofovir
  • Urine / microbiology*

Substances

  • Anti-Infective Agents
  • Organophosphonates
  • Reverse Transcriptase Inhibitors
  • Tenofovir
  • Adenine