A method for the synthesis of an oseltamivir PET tracer

Masataka Morita; Toshihiko Sone; Kenzo Yamatsugu; Yoshihiro Sohtome; Shigeki Matsunaga; Motomu Kanai; Yasuyoshi Watanabe; Masakatsu Shibasaki

doi:10.1016/j.bmcl.2007.11.079

A method for the synthesis of an oseltamivir PET tracer

Bioorg Med Chem Lett. 2008 Jan 15;18(2):600-2. doi: 10.1016/j.bmcl.2007.11.079. Epub 2007 Nov 28.

Authors

Masataka Morita¹, Toshihiko Sone, Kenzo Yamatsugu, Yoshihiro Sohtome, Shigeki Matsunaga, Motomu Kanai, Yasuyoshi Watanabe, Masakatsu Shibasaki

Affiliation

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo 7-3-1 Hongo, Tokyo 113-0033, Japan.

PMID: 18055200
DOI: 10.1016/j.bmcl.2007.11.079

Abstract

A protocol applicable for the synthesis of an oseltamivir positron emission tomography (PET) tracer was developed. Acetylation of amine 3 with CH(3)COCl, followed by deprotection and aqueous workup, produced oseltamivir 4 from 3 within 10 min. The obtained 4 was sufficiently pure for PET studies. This method can be extended to PET tracer synthesis using CH(3)(11)COCl.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / pharmacokinetics*
Oseltamivir / pharmacokinetics*
Positron-Emission Tomography*
Radioisotopes / chemistry*

Substances

Antiviral Agents
Radioisotopes
Oseltamivir