Intracellular mediators of CXCR4-dependent signaling in T cells

Laura Patrussi; Cosima T Baldari

doi:10.1016/j.imlet.2007.10.012

Intracellular mediators of CXCR4-dependent signaling in T cells

Immunol Lett. 2008 Jan 29;115(2):75-82. doi: 10.1016/j.imlet.2007.10.012. Epub 2007 Nov 20.

Authors

Laura Patrussi¹, Cosima T Baldari

Affiliation

¹ Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. patrussi2@unisi.it

PMID: 18054087
DOI: 10.1016/j.imlet.2007.10.012

Abstract

The signaling pathways induced in T lymphocytes by CXCR4-CXCL12 interaction, which lead to the cytoskeletal macro-rearrangements observable in migrating cells, are as yet largely uncharacterized. The aim of this review is to briefly summarize the current knowledge of the signaling machinery which controls the process of chemotaxis in CXCL12-stimulated T lymphocytes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chemotaxis, Leukocyte / physiology
Cytoskeleton / metabolism
Heterotrimeric GTP-Binding Proteins / metabolism
Humans
Intracellular Signaling Peptides and Proteins / metabolism*
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / metabolism*
Receptors, Antigen, T-Cell / metabolism
Receptors, CXCR4 / metabolism*
Signal Transduction
T-Lymphocytes / physiology*

Substances

Intracellular Signaling Peptides and Proteins
Receptors, Antigen, T-Cell
Receptors, CXCR4
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Heterotrimeric GTP-Binding Proteins