[A comparative study of the immunological indices in guinea pigs administered an inactivated Marburg virus]

G M Ignat'ev; A P Agafonov; M A Strel'tsova; V A Kuz'min; G I Maĭnagasheva; G V Spirin; N B Chernyĭ

[A comparative study of the immunological indices in guinea pigs administered an inactivated Marburg virus]

Vopr Virusol. 1991 Sep-Oct;36(5):421-3.

[Article in Russian]

Authors

G M Ignat'ev, A P Agafonov, M A Strel'tsova, V A Kuz'min, G I Maĭnagasheva, G V Spirin, N B Chernyĭ

PMID: 1803779

Abstract

Samples of concentrated and unconcentrated preparations of Marburg virus were studied. The ultrafiltration method helped increase the specific protein content and decrease the common protein content in a preparation. The resistance index increased with an increase of the specific protein content and the maximum (2.63 +/- 0.2) was reached by two immunizations on 0 and 14 days.

Publication types

Comparative Study
English Abstract

MeSH terms

Animals
Antibody Formation
Dose-Response Relationship, Immunologic
Guinea Pigs
Immunity, Cellular
Immunization / methods
Marburg Virus Disease / immunology
Marburg Virus Disease / prevention & control
Marburgvirus / immunology*
Marburgvirus / isolation & purification
Time Factors
Vaccines, Inactivated / immunology
Vaccines, Inactivated / isolation & purification
Viral Vaccines / immunology*
Viral Vaccines / isolation & purification

Substances

Vaccines, Inactivated
Viral Vaccines