Background: Adequate surgical procedure for gastrointestinal stromal tumors (GISTs) arising in the second portion of the duodenum remains controversial.
Materials and methods: Segmental resection of the second portion of the duodenum and Roux-en-Y reconstruction was performed in two patients with duodenal GISTs. In case 1, a huge tumor arising from the second portion of the duodenum occupied the right upper quadrant of the abdomen. Preoperative treatment using imatinib mesylate decreased the tumor size from 22 to 8 cm. In case 2, the tumor was located in the second portion of the duodenum longitudinally. In both of the cases, the major papilla was preserved.
Results: The postoperative course was uneventful, and they were discharged on day 11. Surgical margins were negative.
Conclusion: The present simple segmental duodenectomy can be applied in the treatment of GISTs or other low-grade malignancies.