Effect of n-tyrosol on blood viscosity and platelet aggregation

M B Plotnikov; G A Chernysheva; V I Smol'yakova; M Yu Maslov; I V Cherkashina; A P Krysin; I V Sorokina; T G Tolstikova

doi:10.1007/s10517-007-0017-y

Effect of n-tyrosol on blood viscosity and platelet aggregation

Bull Exp Biol Med. 2007 Jan;143(1):61-3. doi: 10.1007/s10517-007-0017-y.

Authors

M B Plotnikov¹, G A Chernysheva, V I Smol'yakova, M Yu Maslov, I V Cherkashina, A P Krysin, I V Sorokina, T G Tolstikova

Affiliation

¹ Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.

PMID: 18019014
DOI: 10.1007/s10517-007-0017-y

Abstract

Experiments on rats showed that n-tyrosol limited the increase in blood viscosity during thermal exposure at a shear rate of 5-300 sec(-1) and inhibited ADP-induced platelet aggregation. The effects of n-tyrosol are comparable to that of pentoxyphylline.

MeSH terms

Animals
Blood Viscosity / drug effects*
Hemorheology
In Vitro Techniques
Male
Phenylethyl Alcohol / analogs & derivatives*
Phenylethyl Alcohol / pharmacology
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / pharmacology*
Rats
Rats, Wistar

Substances

Platelet Aggregation Inhibitors
4-hydroxyphenylethanol
Phenylethyl Alcohol