Abstract
ESCRT and ESCRT-associated proteins are required during the assembly and release of many RNA viruses, including HIV. Two new papers provide structures for the ESCRT-associated protein ALIX/AIP1 and demonstrate how this protein interacts with HIV Gag. One of these studies provides the clearest evidence to date that ESCRT-III mediates key events in virus release and indicates that there are cellular proteins involved in this process still to be discovered.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Calcium-Binding Proteins / genetics
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Calcium-Binding Proteins / metabolism*
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism*
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Endosomal Sorting Complexes Required for Transport
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Endosomes / metabolism
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Gene Products, gag / genetics
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Gene Products, gag / metabolism
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Guanylate Kinases
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HIV / metabolism*
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HIV / ultrastructure
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HIV Infections / metabolism*
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Humans
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Proteins / genetics
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Proteins / metabolism*
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Virus Assembly
Substances
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Adaptor Proteins, Signal Transducing
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Calcium-Binding Proteins
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Carrier Proteins
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Cell Cycle Proteins
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Endosomal Sorting Complexes Required for Transport
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Gene Products, gag
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PDCD6IP protein, human
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Proteins
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Guanylate Kinases
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MAGI2 protein, human